Klinische FragestellungMorbus Crohn, genetische Prädisposition

NGS + SNP

[Sanger]

Keine ORPHA#, da nicht so selten -

Chronisch rezidivierende Darmentzündung, unterteilt in M. Crohn + Colitis ulcerosa. M. Crohn kann alle Teile des Gastrointestinaltrakts betreffen, am häufigsten jedoch das terminale Ileum und den Dickdarm.

• Alias: Crohn disease
• Alias: Inflammatory bowel disease
• Alias: Regional enteritis
• Allelic: Autoimmune disease, multisystem, infantile-onset, 1 (STAT3)
• Allelic: Blau syndrome (NOD2)
• Allelic: Budd-Chiari syndrome, somatic (JAK2)
• Allelic: Colchicine resistance (ABCB1)
• Allelic: Diabetes, susceptibility to (IL6)
• Allelic: Graft-versus-host disease, protection against (IL10)
• Allelic: HIV-1, susceptibility to (IL10)
• Allelic: Hepatitis B virus, susceptibility to (IL10RB)
• Allelic: Hyper-IgE recurrent infection syndrome (STAT3)
• Allelic: Immunodeficiency 29, mycobacteriosis (IL12B)
• Allelic: Immunodeficiency 35 (TYK2)
• Allelic: Intracranial hemorrhage in brain cerebrovascular malformations, susceptibility (IL6)
• Allelic: Kaposi sarcoma, susceptibility to (IL6)
• Allelic: Multiple sclerosis, susceptibility to, 1 (HLA-DRB1)
• Allelic: Mycobacterium tuberculosis, protection against (IRGM)
• Allelic: Parkinson disease 8 (LRRK2)
• Allelic: Psoriasis, protection against (IL23R)
• Allelic: Rheumatoid arthritis, progression of (IL10)
• Allelic: Rheumatoid arthritis, susceptibility to (SLC22A4)
• Allelic: Rheumatoid arthritis, systemic juvenile (IL6)
• Allelic: Sarcoidosis, susceptibility to, 1 (HLA-DRB1)
• Allelic: Yao syndrome (NOD2)
• Carnitine deficiency, systemic primary (SLC22A5)
• Crohn disease-associated growth failure (IL6)
• Inflammatory bowel disease 1, Crohn disease (NOD2)
• Inflammatory bowel disease 13 (ABCB1)
• Inflammatory bowel disease 17, protection against (IL23R)
• Inflammatory bowel disease 25, early onset, AR (IL10RB)
• Inflammatory bowel disease 28, early onset, AR (IL10RA)
• Inflammatory bowel disease [Crohn disease] 10 (ATG16L1)
• Inflammatory bowel disease, Crohn disease 19 (IRGM)
• Inflammatory bowel disease, Crohn disease 30 (CARD8)
• Inflammatory bowel disease, infantile ulcerative colitis 31 (IL37)