IllnessOvarian cancer, familial; susceptibility

NGS +

Sanger

Ovarian cancers originate in ovaries, fallopian tubes or peritoneum with mild signs/symptoms early on. Some mutations raise the risk for ovarian cancer development, mainly in BRCA1, BRCA2 and Lynch syndrome genes. Among different tumor types, most common is high-grade serous carcinoma (70%). Very early treatment works best.

• Alias: Ovarial-Karzinom
• Allelic: Breast cancer, male, susceptibility to (BRCA2, BRIP1)
• Allelic: Colorectal cancer, hereditary nonpolyposis, type 1 (MSH2)
• Allelic: Colorectal cancer, hereditary nonpolyposis, type 2 (MLH1)
• Allelic: Colorectal cancer, hereditary nonpolyposis, type 4 (PMS2)
• Allelic: Colorectal cancer, hereditary nonpolyposis, type 5 (MSH6)
• Allelic: Colorectal cancer, hereditary nonpolyposis, type 7 (MLH3)
• Allelic: Colorectal cancer, hereditary nonpolyposis, type 8 (EPCAM)
• Allelic: Colorectal cancer, somatic (MLH3)
• Allelic: Diarrhea 5, with tufting enteropathy, congenital (EPCAM)
• Allelic: Endometrial cancer, familial (MSH6)
• Allelic: Endometrial cancer, susceptibility to (MLH3)
• Allelic: Fanconi anemia, complementation group D1 (BRCA2)
• Allelic: Fanconi anemia, complementation group J (BRIP1)
• Allelic: Fanconi anemia, complementation group N (PALB2)
• Allelic: Fanconi anemia, complementation group O (RAD51C)
• Allelic: Fanconi anemia, complementation group S (BRCA1)
• Allelic: Muir-Torre syndrome (MLH1, MSH2)
• Allelic: Pancreatic cancer, susceptibility to, 3 (PALB2)
• Allelic: Wilms tumor (BRCA2)
• Adult solid tumours cancer susceptibility, Lynch syndrome [panelapp] (EPCAM)
• Breast cancer, susceptibility to (PALB2)
• Breast-ovarian cancer, familial, 1 (BRCA1)
• Breast-ovarian cancer, familial, 2 (BRCA2)
• Breast-ovarian cancer, familial, susceptibility to, 3 (RAD51C)
• Breast-ovarian cancer, familial, susceptibility to, 4 (RAD51D)
• Mismatch repair cancer syndrome (MLH1, MSH2, MSH6, PMS2)