IllnessLung cancer, NSCLC; susceptibility + protection
Summary
Short information
A curated panel containing 1 guideline-curated core gene, 3 core candidate genes and altogether 13 genes for the comprehensive analysis of the genetic susceptibility/protection concerning NSCLC pulmonary carcinomas
ID
NP0010
Number of genes
10
Accredited laboratory test
Examined sequence length
6,5 kb (Core-/Core-canditate-Genes)
18,1 kb (Extended panel: incl. additional genes)
18,1 kb (Extended panel: incl. additional genes)
Analysis Duration
on request
Material
- EDTA-anticoagulated blood (3-5 ml)
Diagnostic indications
NGS +
[Sanger]
Gene panel
Selected genes
Name | Exon Length (bp) | OMIM-G | Referenz-Seq. | Heredity |
---|---|---|---|---|
EGFR | 3633 | NM_005228.5 | AD, SMu, Sus | |
SFTPA1 | 792 | NM_001093770.3 | Sus | |
SFTPA2 | 747 | NM_001098668.4 | AD | |
STK11 | 1302 | NM_000455.5 | AD | |
BAP1 | 2190 | NM_004656.4 | AD | |
CASP8 | 1395 | NM_001080124.2 | Sus | |
CYP2A6 | 1485 | NM_000762.6 | AD | |
ERCC6 | 4482 | NM_000124.4 | AD, Sus | |
FASLG | 846 | NM_000639.3 | Sus | |
TP53 | 1182 | NM_000546.6 | AD |
Informations about the disease
Clinical Comment
NSCLC (85% of patients: adenocarcinoma, squamous cell carcinoma, large cell) and small cell lung cancer (SCLC) (15%).
Adenocarcinoma 40% of lung cancers, Squamous cell carcinomas 25%-30% of lung cancers; large cell cancers 5%-10% of all lung cancers
Synonyms
- Allelic: Melanoma, malignant, somatic (STK11)
- Allelic: Pancreatic cancer, somatic (STK11)
- Allelic: Peutz-Jeghers syndrome (STK11)
- Allelic: Testicular tumor, somatic (STK11)
- Lung cancer, protection against (CASP8)
- Lung cancer, resistance to (CYP2A6)
- Lung cancer, somatic (MAP3K8, PPP2R1B, KRAS)
- Lung cancer, susceptibility to (ERCC6, FASLG)
- Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in (EGFR)
- Nonsmall cell lung cancer, somatic (IRF1, PIK3CA)
- Nonsmall cell lung cancer, susceptibility to (EGFR)
- Pulmonary fibrosis, idiopathic (SFTPA2 [SFTPA1])
- Tumor predisposition syndrome (BAP1)
Heredity, heredity patterns etc.
- AD
- SMu
- Sus
OMIM-Ps
- Multiple OMIM-Ps
ICD10 Code
Bioinformatics and clinical interpretation
No text defined