©istock.com/Andrea Obzerova
Interdisciplinary CompetenceMolecular Diagnostics
Know how in the analysis of genetic material.
For the benefit of patients.

IllnessLung cancer, NSCLC; susceptibility + protection

Summary

Short information

A curated panel containing 1 guideline-curated core gene, 3 core candidate genes and altogether 13 genes for the comprehensive analysis of the genetic susceptibility/protection concerning NSCLC pulmonary carcinomas

ID
NP0010
Number of genes
10 Accredited laboratory test
Examined sequence length
6,5 kb (Core-/Core-canditate-Genes)
18,1 kb (Extended panel: incl. additional genes)
Analysis Duration
on request
Material
  • EDTA-anticoagulated blood (3-5 ml)
Diagnostic indications

NGS +

[Sanger]

 

Gene panel

Selected genes

NameExon Length (bp)OMIM-GReferenz-Seq.Heredity
EGFR3633NM_005228.5AD, SMu, Sus
SFTPA1792NM_001093770.3Sus
SFTPA2747NM_001098668.4AD
STK111302NM_000455.5AD
BAP12190NM_004656.4AD
CASP81395NM_001080124.2Sus
CYP2A61485NM_000762.6AD
ERCC64482NM_000124.4AD, Sus
FASLG846NM_000639.3Sus
TP531182NM_000546.6AD

Informations about the disease

Clinical Comment

NSCLC (85% of patients: adenocarcinoma, squamous cell carcinoma, large cell) and small cell lung cancer (SCLC) (15%).

Adenocarcinoma 40% of lung cancers, Squamous cell carcinomas 25%-30% of lung cancers; large cell cancers 5%-10% of all lung cancers

 

Synonyms
  • Allelic: Melanoma, malignant, somatic (STK11)
  • Allelic: Pancreatic cancer, somatic (STK11)
  • Allelic: Peutz-Jeghers syndrome (STK11)
  • Allelic: Testicular tumor, somatic (STK11)
  • Lung cancer, protection against (CASP8)
  • Lung cancer, resistance to (CYP2A6)
  • Lung cancer, somatic (MAP3K8, PPP2R1B, KRAS)
  • Lung cancer, susceptibility to (ERCC6, FASLG)
  • Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in (EGFR)
  • Nonsmall cell lung cancer, somatic (IRF1, PIK3CA)
  • Nonsmall cell lung cancer, susceptibility to (EGFR)
  • Pulmonary fibrosis, idiopathic (SFTPA2 [SFTPA1])
  • Tumor predisposition syndrome (BAP1)
Heredity, heredity patterns etc.
  • AD
  • SMu
  • Sus
OMIM-Ps
  • Multiple OMIM-Ps
ICD10 Code

Bioinformatics and clinical interpretation

No text defined