Deutsch
IllnessKolonkarzinom, POLE related
Summary
Short information
Curated single gene sequence analysis according to the clinical suspicion colon cancer, POLE related
ID
KS0095
Number of genes
1
Accredited laboratory test
Examined sequence length
6,9 kb (Core-/Core-canditate-Genes)
- (Extended panel: incl. additional genes)
- (Extended panel: incl. additional genes)
Analysis Duration
on request
Material
- EDTA-anticoagulated blood (3-5 ml)
Diagnostic indications
NGS +
Gene panel
Selected genes
| Name | Exon Length (bp) | OMIM-G | Referenz-Seq. | Heredity |
|---|---|---|---|---|
| POLE | 6861 | NM_006231.4 | AD |
Informations about the disease
Clinical Comment
Special CRC - POLE gene associated.
CRC as common disease, the 3.rd most frequent cancer in men, the 2.nd most frequent in women. Family history is a major risk factor for the development of CRC. Familial aggregation of this disease is observed in 25%. The risk for CRC is increased in individuals with a personal or family medical history of colorectal polyps.
Synonyms
- Alias: Colon-Ca.
- Alias: Darmkrebs
- Alias: Kolorektalkarzinom
- Alias: Polymerase proofreading-related adenomatous polyposis
- Alias: Rektum-Ca.
- Allelic: Facial dysmorphism-immunodeficiency-livedo-short stature [FILS] syndrome (POLE)
- Allelic: IMAGE-I syndrome (POLE)
- Colorectal cancer, susceptibility to, 12 (POLE)
Heredity, heredity patterns etc.
- AD
OMIM-Ps
ICD10 Code
Bioinformatics and clinical interpretation
No text defined