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Interdisciplinary CompetenceMolecular Diagnostics
Know how in the analysis of genetic material.
For the benefit of patients.

IllnessHead and neck cancer, susceptibility

Summary

Short information

Comprehensive differential diagnostic panel for Head and neck cancer (susceptibility) comprising 10 or 19 curated genes according to the clinical signs

ID
HP7485
Number of genes
18 Accredited laboratory test
Examined sequence length
22,1 kb (Core-/Core-canditate-Genes)
42,6 kb (Extended panel: incl. additional genes)
Analysis Duration
on request
Material
  • EDTA-anticoagulated blood (3-5 ml)
Diagnostic indications

NGS +

[Sanger]

 

Gene panel

Selected genes

NameExon Length (bp)OMIM-GHeredity
BRIP13750AR
FANCA4368AR
FANCB2580Sus
FANCC1677Sus
FANCE1611AR, Sus
FANCF1125Sus
FANCG1869Sus
FANCI3987Sus
FANCL1128Sus
FANCM6147AR, Sus
HMGA2330Sus
ING1789SMu
NFKBIA954AD
PLAG11503Gen Fusion
PRKD12739AD
PTEN1212AD
SLX45505AR
TNFRSF10B1323AD

Informations about the disease

Clinical Comment

Despite classical environmental risk factors like tobacco, alcohol and viral infection, not all individuals develop head and neck cancer. Therefore, identification of the genetic susceptibility remains important. Candidate SNPs reside in genes within well-known carcinogenic pathways (oncogenesis, tumour suppression, DNA repair, inflammation, oxidation, apoptosis).

 

Synonyms
  • Alias: Squamous cell carcinoma, head and neck; susceptibility
  • Adenomas, salivary gland pleomorphic, somatic (PLAG1)
  • Alias: Squamous cell carcinoma, head and neck, somatic (ING)
  • Alias: Squamous cell carcinoma, head and neck (TNFRSF10B)
  • Allelic: Breast cancer, early-onset, susceptibility to (BRIP1)
  • Allelic: Congenital heart defects and ectodermal dysplasia (PRKD1)
  • Allelic: Cowden syndrome 1 (PTEN)
  • Allelic: Ectodermal dysplasia and immunodeficiency 2 (NFKBIA)
  • Allelic: Fanconi anemia, complementation group A (FANCA)
  • Allelic: Fanconi anemia, complementation group B (FANCB)
  • Allelic: Fanconi anemia, complementation group C (FANCC)
  • Allelic: Fanconi anemia, complementation group D2 (FANCD2)
  • Allelic: Fanconi anemia, complementation group E (FANCE)
  • Allelic: Fanconi anemia, complementation group F (FANCF)
  • Allelic: Fanconi anemia, complementation group G (FANCG)
  • Allelic: Fanconi anemia, complementation group I (FANCI)
  • Allelic: Fanconi anemia, complementation group J (BRIP1)
  • Allelic: Fanconi anemia, complementation group L (FANCL)
  • Allelic: Fanconi anemia, complementation group M (FANCM)
  • Allelic: Fanconi anemia, complementation group P (SLX4)
  • Allelic: Glioma susceptibility 2 (PTEN)
  • Allelic: Lhermitte-Duclos syndrome (PTEN)
  • Allelic: Macrocephaly/autism syndrome (PTEN)
  • Allelic: Meningioma (PTEN)
  • Allelic: Prostate cancer, somatic (PTEN)
  • Allelic: Silver-Russell syndrome 4 (PLAG1)
  • Allelic: Silver-Russell syndrome 5 (HMGA2)
Heredity, heredity patterns etc.
  • AD
  • AR
  • Gen Fusion
  • SMu
  • Sus
OMIM-Ps
  • Multiple OMIM-Ps
ICD10 Code
C76.0

Bioinformatics and clinical interpretation

No text defined