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Interdisciplinary CompetenceMolecular Diagnostics
Know how in the analysis of genetic material.
For the benefit of patients.

IllnessHead and neck cancer, susceptibility

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Summary

Short information

Comprehensive differential diagnostic panel for Head and neck cancer, susceptibility, containing 10 or 19 curated genes according to the clinical signs

ID
HP7485
Number of genes
18 Accredited laboratory test
Examined sequence length
22,1 kb (Core-/Core-canditate-Genes)
42,6 kb (Extended panel: incl. additional genes)
Analysis Duration
on request
Material
  • EDTA-anticoagulated blood (3-5 ml)
Diagnostic indications

NGS +

[Sanger]

 

Gene panel

Selected genes

NameExon Length (bp)OMIM-GReferenz-Seq.Heredity
BRIP13750NM_032043.3AR
FANCA4368NM_000135.4AR
FANCB2580NM_001018113.3Sus
FANCC1677NM_000136.3Sus
FANCE1611NM_021922.3AR, Sus
FANCF1125NM_022725.4Sus
FANCG1869NM_004629.2Sus
FANCI3987NM_001113378.2Sus
FANCL1128NM_018062.4Sus
FANCM6147NM_020937.4AR, Sus
HMGA2330NM_003483.6Sus
ING1789NM_001267728.1SMu
NFKBIA954NM_020529.3AD
PLAG11503NM_002655.3Gen Fusion
PRKD12739NM_002742.3AD
PTEN1212NM_000314.8Sus, SMu
SLX45505NM_032444.4AR
TNFRSF10B1323NM_003842.5AR

Informations about the disease

Clinical Comment

Despite classical environmental risk factors like tobacco, alcohol and viral infection, not all individuals develop head and neck cancer. Therefore, identification of the genetic susceptibility remains important. Candidate SNPs reside in genes within well-known carcinogenic pathways (oncogenesis, tumour suppression, DNA repair, inflammation, oxidation, apoptosis).

 

Synonyms
  • Alias: Squamous cell carcinoma, head and neck, somatic (ING)
  • Alias: Squamous cell carcinoma, head and neck (TNFRSF10B)
  • Alias: Squamous cell carcinoma, head and neck; susceptibility
  • Allelic: Breast cancer, early-onset, susceptibility to (BRIP1)
  • Allelic: Congenital heart defects and ectodermal dysplasia (PRKD1)
  • Allelic: Cowden syndrome 1 (PTEN)
  • Allelic: Ectodermal dysplasia and immunodeficiency 2 (NFKBIA)
  • Allelic: Fanconi anemia, complementation group A (FANCA)
  • Allelic: Fanconi anemia, complementation group B (FANCB)
  • Allelic: Fanconi anemia, complementation group C (FANCC)
  • Allelic: Fanconi anemia, complementation group D2 (FANCD2)
  • Allelic: Fanconi anemia, complementation group E (FANCE)
  • Allelic: Fanconi anemia, complementation group F (FANCF)
  • Allelic: Fanconi anemia, complementation group G (FANCG)
  • Allelic: Fanconi anemia, complementation group I (FANCI)
  • Allelic: Fanconi anemia, complementation group J (BRIP1)
  • Allelic: Fanconi anemia, complementation group L (FANCL)
  • Allelic: Fanconi anemia, complementation group M (FANCM)
  • Allelic: Fanconi anemia, complementation group P (SLX4)
  • Allelic: Glioma susceptibility 2 (PTEN)
  • Allelic: Lhermitte-Duclos syndrome (PTEN)
  • Allelic: Macrocephaly/autism syndrome (PTEN)
  • Allelic: Meningioma (PTEN)
  • Allelic: Prostate cancer, somatic (PTEN)
  • Allelic: Silver-Russell syndrome 4 (PLAG1)
  • Allelic: Silver-Russell syndrome 5 (HMGA2)
  • Adenomas, salivary gland pleomorphic, somatic (PLAG1)
Heredity, heredity patterns etc.
  • AD
  • AR
  • Gen Fusion
  • SMu
  • Sus
OMIM-Ps
  • Multiple OMIM-Ps
ICD10 Code

Bioinformatics and clinical interpretation

No text defined