©istock.com/Andrea Obzerova

Interdisciplinary CompetenceMolecular Diagnostics

Know how in the analysis of genetic material.
For the benefit of patients.

IllnessBladder cancer, susceptibility

Request form illness

Summary

Short information

A curated panel containing 4 or 6 genes, respectively, for the analysis of the genetically caused forms of bladder cancer

ID

BP7654

Number of genes

6 Accredited laboratory test

Examined sequence length

11,8 kb (Core-/Core-canditate-Genes)
31,2 kb (Extended panel: incl. additional genes)

Analysis Duration

on request

Material

EDTA-anticoagulated blood (3-5 ml)

Diagnostic indications

NGS + Sanger

Gene panel

Selected genes

Name	Exon Length (bp)	OMIM-G	Referenz-Seq.	Heredity
MLH1	2271	120436	NM_000249.4	AD, Sus
MSH2	2805	609309	NM_000251.3	AD, Sus
MSH6	4083	600678	NM_000179.3	AD, Sus
PMS2	2589	600259	NM_000535.7	AD
ATM	9171	607585	NM_000051.4	AR
BRCA2	10257	600185	NM_000059.4	Sus

Informations about the disease

Clinical Comment

Group of disorders

Synonyms

Alias. Unrinary bladder carcinoma
Alias: Blasenkrebs
Allelic: Breast cancer, male, susceptibility to (BRCA2)
Allelic: Breast cancer, susceptibility to (ATM)
Allelic: Breast-ovarian cancer, familial, 2 (BRCA2)
Allelic: Colorectal cancer, hereditary nonpolyposis, type 1 (MSH2)
Allelic: Colorectal cancer, hereditary nonpolyposis, type 2 (MLH1)
Allelic: Colorectal cancer, hereditary nonpolyposis, type 4 (PMS2)
Allelic: Colorectal cancer, hereditary nonpolyposis, type 5 (MSH6)
Allelic: Endometrial cancer, familial (MSH6)
Allelic: Glioblastoma 3 (BRCA2)
Allelic: Medulloblastoma (BRCA2)
Allelic: Muir-Torre syndrome (MLH1, MSH2)
Allelic: Pancreatic cancer 2 (BRCA2)
Allelic: Prostate cancer (BRCA2)
Allelic: Wilms tumor (BRCA2)
Ataxia-telangiectasia (ATM)
Fanconi anemia, complementation group D1 (BRCA2)
Mismatch repair cancer syndrome (MLH1, MSH2, MSH6, PMS2)

Heredity, heredity patterns etc.

AD
AR
Sus

OMIM-Ps

Multiple OMIM-Ps

ICD10 Code

Bioinformatics and clinical interpretation

No text defined