IllnessStatin toxicity

Summary

Short information

Comprehensive differential diagnostic panel for Statin toxicity containing 2 core candidate genes and altogether 6 curated genes according to the clinical signs

SP4222

Number of genes

5 Accredited laboratory test

Examined sequence length

2,1 kb (Core-/Core-canditate-Genes)
15,1 kb (Extended panel: incl. additional genes)

Analysis Duration

on request

Material

EDTA-anticoagulated blood (3-5 ml)

Diagnostic indications

NGS

Gene panel

Selected genes

Name	Exon Length (bp)	OMIM-G	Referenz-Seq.	Heredity
SLCO1B1	2076	604843	NM_006446.5	digenisch, AR
ABCB1	3843	171050	NM_000927.5	Resistenz
ABCC2	4638	601107	NM_000392.5	AR
ABCG2	1836	603756	NM_001257386.2	Resistenz
HMGCR	2667	142910	NM_000859.3	Mult

Informations about the disease

Clinical Comment

Statins are prescribed to lower cholesterol. In spite of wide-spread use, discontinuation and nonadherence cause gaps in the prevention of atherosclerotic cardiovascular disease. Major reasons are statin-associated muscle symptoms and other statin-induced side effects, like new-onset of type 2 diabetes mellitus, neurological/neurocognitive effects, hepato- and renal toxicity.

Synonyms

Colchicine resistance (ABCB1)
Hyperbilirubinemia, Rotor type, digenic (SLCO1B1)
Inflammatory bowel disease 13 (ABCB1)
Low density lipoprotein cholesterol level QTL 3 (HMGCR)
Statins, attenuated cholesterol lowering by (HMGCR)
Uric acid concentration, serum, QTL1 (ABCG2)
[Statin intolerance + statin-induced myalgia; lit.] (LILRB5)

Heredity, heredity patterns etc.

AR
Mult
Resistenz
digenisch

OMIM-Ps

Multiple OMIM-Ps

ICD10 Code

Bioinformatics and clinical interpretation

No text defined