IllnessMorbus Menière, familial; differential diagnosis

Summary

Short information

A curated panel containing 4 or 6 genes, respectively, for the comprehensive analysis of the suspected Morbus Menière, familial

MP0170

Number of genes

5 Accredited laboratory test

Examined sequence length

5,3 kb (Core-/Core-canditate-Genes)
5,9 kb (Extended panel: incl. additional genes)

Analysis Duration

on request

Material

EDTA-anticoagulated blood (3-5 ml)

Diagnostic indications

NGS +

Gene panel

Selected genes

Name	Exon Length (bp)	OMIM-G	Referenz-Seq.	Heredity
COCH	1653	603196	NM_004086.3	AD
DTNA	1116	601239	NM_001128175.2	AD
FAM136A	417	616275	NM_032822.3	AD
PRKCB	2022	176970	NM_002738.7	AD
DPT	610	125597	NM_001937.5	AD

Informations about the disease

Clinical Comment

Chronic illness characterized by intermittent episodes of vertigo lasting from min-h, with fluctuating sensorineural hearing loss, tinnitus + aural pressure

Synonyms

Symptoms: Vertigo episodes, fluctuating sensorineural hearing loss, tinnitus, aural pressure
Alias: Auditory vertigo
Alias: Aural vertigo
Alias: Otogenic vertigo
Alias: Primary endolymphatic hydrops
Allelic: Left ventricular noncompaction 1, with/-out congenital heart defects (DTNA)
Deafness, AD 9 (COCH)
Deafness, AR 110 (COCH)
Menière "watchlist" [panelapp] (DPT)
Susceptibility to Meniere disease (FAM136A)
Susceptibility to Meniere disease (PRKCB1)

Heredity, heredity patterns etc.

OMIM-Ps

Multiple OMIM-Ps

ICD10 Code

Bioinformatics and clinical interpretation

No text defined