IllnessPancreatic cancer, after chronic pancreatitis; differential diagnosis
Summary
A curated panel containing 2 guideline-curated genes and altogether 5 gehes for the comprehensive analysis of the genetically caused forms of Pancreatic cancer after chronic pancreatitis
1,8 kb (Extended panel: incl. additional genes)
- EDTA-anticoagulated blood (3-5 ml)
NGS +
[Sanger]
Gene panel
Informations about the disease
Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a five-year survival rate of <6%. Chronic pancreatitis is a strong risk factor for PDAC. In addition to common epidemiologic risk factors, several genetic polymorphisms are known susceptibility loci for, both, chronic pancreatitis and PDAC. Included in the given panel are genes that account for cancer development risks based on chronic pancreatitis. Therefore, the core message of these studies usually concerns relative risks for PDAC. Inheritance is multifactorial; extensive study results on diagnostic yield are not available.
https://pubmed.ncbi.nlm.nih.gov/28913878/
https://pubmed.ncbi.nlm.nih.gov/30894932/
- Alias: Pancreatic cancer; Pancreatic carcinoma
- Allelic: Fibrocalculous pancreatic diabetes, susceptibility to (SPINK1)
- Hereditary chronic pancreatitis [panelapp] (CPA1)
- Pancreatitis, chronic, susceptibility to (CTRC)
- Pancreatitis, hereditary (CFTR)
- Pancreatitis, hereditary (PRSS1)
- Pancreatitis, hereditary (SPINK1)
- Tropical calcific pancreatitis (SPINK1)
- AD
- n.k.
- Multiple OMIM-Ps
Bioinformatics and clinical interpretation
No text defined