IllnessLupus erythematodes Suszeptibilität

Summary

Short information

Comprehensive panel for determining the susceptibility for Lupus erythematosus comprising 25 curated genes according to the clinically suspected diagnosis

LP8585

Number of genes

25 Accredited laboratory test

Examined sequence length

0,9 kb (Core-/Core-canditate-Genes)
51,7 kb (Extended panel: incl. additional genes)

Analysis Duration

on request

Material

EDTA-anticoagulated blood (3-5 ml)

Diagnostic indications

NGS + SNP

Gene panel

Selected genes

Name	Exon Length (bp)	OMIM-G	Heredity
DNASE1L3	828	602244	AR
BANK1	2268	610292	Ass
C4A	5097	120810	Sus
C4B	5235	120820	Sus
CR2	3279	120650	AR, Sus
CRP	675	123260	Ass
CTLA4	525	123890	AD
DNASE1	849	125505	Sus
FCGR2A	954	146790	Sus
FCGR2B	873	604590	AD, Sus
IRF5	1497	607218	Sus
ITGAM	3459	120980	Ass
KIRREL3	1803	607761	Ass
LTK	2205	151520	Ass
NCF2	1581	608515	AR, Sus
NLRP1	4422	606636	AD, AR
PDCD1	867	600244	AR
PTPN22	2340	600716	AR
RASGRP1	2289	603962	AD
SAMHD1	1881	606754	AR
STAT4	2247	600558	AD
TLR5	2577	603031	Ass
TNFAIP3	2373	191163	Ass
TNFSF4	552	603594	AR
TREX1	945	606609	AD

Informations about the disease

Clinical Comment

Lupus erythematodes is a complex multisystem and a heterogenous inflammatory autoimmune disorder with the potential involvement of many organs (kidneys, skin, joints, lungs, cardiovascular system, central nervous system, hematopoietic system) and variable course. Systemic vs. cutanous Lupus

Synonyms

Alias: Systemic lupus erythematodes, SLE
see Synonyme / allelische Krankheiten (mit mutierten Genen) under LP8586

Heredity, heredity patterns etc.

OMIM-Ps

Multiple OMIM-Ps

ICD10 Code

L93.-

Bioinformatics and clinical interpretation

No text defined