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Interdisciplinary CompetenceMolecular Diagnostics
Know how in the analysis of genetic material.
For the benefit of patients.

IllnessAlcohol intolerance


Short information

A curated panel containing 3 genes for the comprehensive analysis of the genetically caused forms of alcohol intolerance

Number of genes
3 Accredited laboratory test
Examined sequence length
2,7 kb (Core-/Base-Genes)
3,9 kb (Extended panel)
Analysis Duration
on request
  • EDTA-anticoagulated blood (3-5 ml)
Diagnostic indications



Gene panel

Selected genes

NameExon Length (bp)OMIM-GHeredity
ADH1C1128AD and/or Mult and/or Sus

Informations about the disease

Clinical Comment

Alcohol intolerance is a genetic metabolic disorder triggered by ethanol consumption. Alcohol intolerance is associated with a combination of certain ADH1B, ALDH2 and possibly ADH1C gene variants that affect the ethanol-neutralizing metabolism. Higher levels of acetaldehyde trigger the below-mentioned symptoms because the above-mentioned enzymes metabolize alcohol inefficiently. The gene variants in question are most commonly detected in people of East Asian descent, in whom alcohol intolerance is a more common problem leading to skin flushing, rashes, nausea and vomiting, diarrhea, low blood pressure, palpitations and drowsiness.

Reference: -


  • Allelic: Aerodigestive tract cancer, squamous cell, alcohol-related, protection against (ADH1B)
  • Allelic: Esophageal cancer, alcohol-related, susceptibility to (ALDH2)
  • Allelic: Parkinson disease, susceptibility to (ADH1C)
  • Allelic: Sublingual nitroglycerin, susceptibility to poor response to (ALDH2)
  • Alcohol dependence, protection against (ADH1B)
  • Alcohol dependence, protection against (ADH1C)
  • Alcohol sensitivity, acute (ALDH2)
  • Hangover, susceptibility to (ALDH2)
Heredity, heredity patterns etc.
  • AD
  • AD and/or Mult and/or Sus
  • Mult
  • Multiple OMIM-Ps
ICD10 Code

Bioinformatics and clinical interpretation

No text defined